| 摘要 |
PURPOSE:To economically produce the titled compound useful as a raw material for medicines by simple operation in a short time, by subjecting benzyl chloride and hydroxyphenones to dehydrochlorination reaction using methyl isobutyl ketone as a solvent. CONSTITUTION:Benzyl chloride and hydroxyphenones are reacted preferably in the presence of a dehydrochlorinating agent, such as potassium carbonate, in methyl isobutyl ketone as a reaction solvent to afford the aimed benzyloxyphenones expressed by the formula (R is H, alkyl or phenyl; R1 and R2 are H, alkyl, alkoxy or phenyl). The reaction temperature for carrying out the reaction is the refluxing temperature of the methyl isobutyl ketone, i.e. 105-115 deg.C, and the amount of the methyl isobutyl ketone used is 300-600g, preferably 400-500g based on 1mol. hydroxyphenones. Hydrolysis of the benzyl chloride can be suppressed and amount of thereof used can be reduced by this method.
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