发明名称 |
PHARMACEUTICAL COMPOSITION CONTAINING UROKINASE |
摘要 |
A pharmaceutical composition containing urokinase and a physiological absorption enhancer comprising higher fatty acids, a polyalkylene glycol and calcium is disclosed. Whereas urokinase which is decomposed and inactivated in the stomach and is poorly absorbed from the intestinal tract cannot be orally administered, it can be orally administered in the form of the present composition by applying an enteric coating, because urokinase in the composition is highly absorbable from the intestinal tract. It is desirable in the present composition in view of the stability and sustained absorbability that urokinase is contained in said composition in the form of a liposome preparation in which the urokinase is incorporated in voids of the liposome. The components are incorporated in the present composition at a ratio of 0.01-2 mg. of the higher fatty acid, 0.01-5 mg. of the polyalkylene glycol and 0.0001-0.1 mg. of the calcium per 100 units of urokinase. The present composition is satisfactory for use as a thrombolytic agent. |
申请公布号 |
DE3474511(D1) |
申请公布日期 |
1988.11.17 |
申请号 |
DE19843474511 |
申请日期 |
1984.10.09 |
申请人 |
TERUMO KABUSHIKI KAISHA TRADING AS TERUMO CORPORATION |
发明人 |
NAKAGAME, FUJIO;HONDA, HARUO;MARUYAMA, TEPPEI;SAITO, NORIKO;KIMOTO, TOMOAKI |
分类号 |
A61K9/127;A61K9/20;A61K9/48;A61K38/49;A61K47/00;A61K47/10;(IPC1-7):A61K37/547;A61K9/50 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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