| 摘要 |
The invention relates to dihydro- and tetrahydroisoquinolines and their physiologically acceptable salts of formula (I) or (I'), in which formulae A is -CH= or -N=, n is 0 or 1, R1 and R2 are the same or different and designate H, halogen, OH, a C1-C4 alkoxy, R3 is H when R1 and R2 are H, or halogen or a C1-C6 alkyl group, R4 is halogen, a C1-C6 alkyl group or designates an amino group of formula (II), where R5 and R6 are the same or different and designate H or a C1-C3 alkyl group which can be substituted with a phenyl group substituted with one or two lower alkoxy, and R4 can also be H when A is -N=. The invention also relates to a method for preparing same whereby an amide of formula (III), where R1-R4 and A have the above significance, is cyclisized with Lewis acid; and the use of compounds of the formula (I) or (I') or their physiologically acceptable derivatives or salts as therapeutical agents. |
