RECOMBINANT SYSTEMS FOR EXPRESSION OF CHOLERA B-SUBUNIT WITH THE AID OF FOREIGN PROMOTERS AND/OR LEADER PEPTIDES

摘要

Procedures are described whereby with the aid of recombinant DNA methods the expression of the binding subunit protein of cholera toxin (CTB) or derivatives thereof including hybrid gene fusion proteins to CTB has been brought under control of a foreign (non-cholera toxin) promoter and/or the CTB protein or its derivatives is being synthesized with a foreign rather than the natural leader peptide to facilitate translocation across cell membranes.