DOPAMINE-BETA-HYDROXYLASE INHIBITORS

摘要

Compounds of Formula : in which n is 0 to 5, R is hydrogen or C1-4alkyl and X is hydrogen, halo, C1-4alkyl, CN, NO2, SO2NH2, COOH, CHO, OH, CH2OH, C1-4alkoxy, CF3, SO2CH3, SO2CF3 or CO2CaH2a+1 wherein a is 1 to 5 or any synthetically accessible combination thereof of up to 5 substituents or any pharmaceutically acceptable salt or hydrate thereof, processes for their preparation, pharmaceutical compositions containing them and their use in therapy as dopamine beta -hydroxylase inhibitors.