发明名称 |
FOERFARANDE FOER FRAMSTAELLNING AV 5-(CYAN ELLER KARBANYL)-/3-4'-BIPYRIDIN/-6(1H)-ON OCH IMINIUMSALT TILL ANVAENDNING SOM MELLANPRODUKT I FOERFARANDET. |
摘要 |
Amrinone intermediates are prepared by reacting 4-picoline with at least three mole equivalents of phosgene per mole of 4-picoline and excess dimethylformamide to produce N-[3-dimethylamino-2-(4-pyridinyl)-2-propenylidene]-N-methylmethaniminium chloride hydrochloride, then reacting the latter with Q-CH2CONH2 and at least three mole equivalents of base in anhydrous medium and then neutralizing the reaction mixture to produce 5-Q-[3,4'-bipyridin]-6(1H)-one, where Q is cyano or carbamyl. Other aspects of the invention are the separate steps of preparing said iminium salt and then converting it to said 5-Q-[3,4'-bipyridin]-6(1H)-one, and also cardiotonic composition and method for increasing cardiac contractility using said iminium salt or pharmaceutically-acceptable acid-addition salt thereof as the active cardiotonic. |
申请公布号 |
FI76787(B) |
申请公布日期 |
1988.08.31 |
申请号 |
FI19810000582 |
申请日期 |
1981.02.25 |
申请人 |
STERLING DRUG INC. |
发明人 |
GELOTTE, KARL OLAF;OPALKA, JR., CHESTER JOSEPH |
分类号 |
A61K31/44;A61K31/4409;A61P9/04;C07D213/53;C07D213/82;C07D213/84;C07D213/85 |
主分类号 |
A61K31/44 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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