发明名称 AROYL BENZOFURAN AND BENZOTHIOPENE ACETIC AND PROPIONIC ACIDS
摘要 <p>Novel aroyl-substituted benzofuran and benzothiophene acetic and proprionic acids are disclosed herein having the formula (I) or a pharmaceutically acceptable salt thereof, and the individual (1) and (d) isomers of the propionic acid or propionate compounds, wherein R1 is hydrogen, hydroxy, lower alkoxy or methyl; R2 is hydrogen or methyl; R3 is hydrogen, alkyl, phenyl, phenyl lower alkyl, 2-furyl, 3-furyl, 2-thienyl, 3-thienyl, wherein the R groups are the same and are lower alkyl; X1 is oxygen or is sulfur if R1 is hydrogen; X2 is oxygen or sulfur; Ar is phenyl unsubstituted or independently substituted with one or more substituents which are lower alkyl, lower alkoxy, halo, lower alkylsulfinyl, lower alkylsulfonyl, lower alkylthio, 2-furyl, 3-furyl, 2-thienyl, or 3-thienyl; and the dotted line represents a single or double bond. These compounds are useful as analgesic, anti-inflammatory, and antipyretic agents.</p>
申请公布号 CA1241008(A) 申请公布日期 1988.08.23
申请号 CA19840458906 申请日期 1984.07.13
申请人 SYNTEX (U.S.A.) INC. 发明人 DUNN, JAMES P.
分类号 C07D333/60;A61K31/34;A61K31/343;A61K31/38;A61K31/381;A61P25/04;A61P29/00;C07C45/68;C07D307/78;C07D307/79;C07D307/80;C07D307/83;C07D333/00;C07D333/52;C07D333/54;C07D407/06;C07D407/12;C07D409/06;(IPC1-7):C07D307/80;C07D407/00 主分类号 C07D333/60
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