| 摘要 |
NEW MATERIAL:A compound shown by formula I (R<1> is H, halogen, OH, lower alkoxy or acylamino; R<2> and R<3> are H, (substituted)N-containing heterocyclic group, alkyl which may contain substituent group (mono or dialkylamino or N-containing heterocyclic group) or R<2> and R<3> together with neighboring 3N form (substituted)N-containing heterocyclic group; Y is alkylene or CO; A is single bond, CO or alkylene; X is O, S, (alkyl-substituted)imino] and a salt thereof. EXAMPLE:5-(4-Methylpiperazin-1-ylcarbonyl)-4-(3-nitrophenyl)-2-phenylt hiazole. USE:A remedy for cerebrovascular diseases such as cerebral apoplexy, cerebral infarct, transient ischemic attack. PREPARATION:For example, a 2-phenyl-5-azolecarboxylic acid derivative shown by formula II is amidated with an amine shown by formula III to give a compound shown by formula I wherein Y is CO.
|
