Process for the biotechnological preparation of optically active alpha-arylalkanoic acids

摘要

There is described the preparation of S(+) alpha-aryl-alkanoic acids by means of the reaction of a racemic ester(R,S) of the formula: (I) wherein: R is a group selected from the group consisting of -C 3BOND CH, a -CH=CH2, -CN; -COCH3, -COO alkyl C1C4 and -CH2-O alkyl C1-C4 group, Ar is a group selected from the group consisting of an aryl group and an aryl substituted or condensed with other groups, in particular a group selected from the group consisting of groups of the formula: (II) and (III) wherein: R' is selected from the group consisting of C1-C8 linear or branch of chain alkyl, C1-C4 alkenyl, alkoxy, phenyl, phenoxy, tenoyl and heterocyclic; R'' is selected from the group consisting of hydrogen or halogen; R''' is a C1-C4 alkyl, with an esterase, produced by microorganisms capable of selectively hydrolizing the S(+) form of said racemic ester and by successively separating the S(+) acid from the unreacted ester.