| 发明名称 |
14,15-SUBSTITUTED LANOSTEROLS AND THEIR USE AS HYPOCHOLESTEROLEMIC AGENTS |
| 摘要 |
Lanosterols substituted in the 14 and/or 15 position(s) which are active in inhibiting lanosta-8,24-dien-3 beta -ol 14 alpha -methyl-demethylase activity, supressing 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) activity, decreasing cholesterol synthesis and reducing serum cholesterol levels are disclosed. |
| 申请公布号 |
AU1117188(A) |
申请公布日期 |
1988.08.04 |
| 申请号 |
AU19880011171 |
申请日期 |
1988.02.01 |
| 申请人 |
E.I. DU PONT DE NEMOURS AND COMPANY |
发明人 |
JAMES LEROY GAYLOR;PAUL ROBERT JOHNSON;SOO SUNG KO;RONALD LOUIS MAGOLDA;SIMON HENDRIK STAM;JAMES MICHAEL TRZASKOS |
| 分类号 |
C07J9/00;C07J41/00;C07J71/00 |
主分类号 |
C07J9/00 |
| 代理机构 |
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代理人 |
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| 地址 |
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