| 摘要 |
<p>Immunoneutering of mammalian animals is achieved by vaccinating the animals with a composition comprising an immunogenic protein such as bovine serum albumin, conjugated with a peptide selected from the group comprising any continuous 5, 6 or 7 amino-acid fragment of the decapeptide pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 (being lutenising hormone releasing hormone) and a suitable immunoadjuvant such as diethylaminoethyl dextran, or emulsions of diethylaminoethyl dextran in a mineral oil. The peptide fragments containing the pGlu from the N terminal or the Gly-NH2 from the C terminal of the decapeptide are preferred for use in such immunogenic compositions.</p> |
