| 摘要 |
A compound of formula I <IMAGE> I wherein R is H or R'CO wherein R'CO is an acyl radical of a carboxylic acid, Y1 is the radical linked to an alpha carbon atom an alpha -amino acid, Y2 is the radical linked to an alpha carbon atom of an alpha -amino acid, <IMAGE> -CH2-S-S-CH2-CH2-COOH, -(CH2)p-COOH or -CH2-S-Y3, Y3 is (C1-4)alkyl or benzyl optionally substituted by methyl or methoxy, or CH3CO-NH-CH2-, n is 1 to 4, A6 is Thr or D-Thr, p is 3 to 5, A8 is the aminoacyl radical of a neutral, lipophilic L- alpha -aminoacid, A9 is the aminoacyl radical of a neutral, lipophilic L- or D- alpha -aminoacid, Z is a polypeptide radical corresponding to the polypeptide radical in positions 10 to 31 of a natural calcitonin or a derivative or analogue thereof having a hypocalcemic effect, wherein, when there is more than one Y1 radical, these are the same or different, and with the exception of radical A8, all amino acid radicals may have the L- or D-configuration, with the proviso that when Y2 is -CH2-SH and n is 4, then the N terminal aminoacyl radical is other than H-CyS, have calcitonin like activity.
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