摘要 |
Certain novel 2-acetoxybenzoyl and ring-substituted alpha -arylpropionyl derivatives of 4-hydroxy-2-methyl-N-(2-pyridinyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide and several other closely-related known oxicams have been prepared. These particular compounds are useful in therapy as non-steroidal anti-arthritic agents. Typical member compounds include 4-(2-acetoxybenzoyloxy)-2-methyl-N-(2-pyridinyl)-2H-1,2-benzothiazine- 3-carboxamide 1,1-dioxide, 4-[ alpha -(4-isobutylphenyl)propionyloxy]-2-methyl-N-(2-pyridinyl)-2H-1,2-benzo thiazine-3-carboxyamide N-(2-pyridinyl)-2H-1,2-benzothiazine-3-carboxyamide 1,1-dioxide, 4-[ alpha -(3-benzoylphenyl)propionyloxy]-2-methyl-N-(2-pyridinyl)-2H-1,2-benzot hiazine-3-carboxamide 1,1-dioxide, "d-4-[ alpha -6-methoxynaphth-2-yl)propionyloxy]-2-methyl-N-(2-pyridinyl)-2H-1,2-be nzothiazine-3-carboxamide 1,1-dioxide" to -- d-4-[ alpha -(6-methoxynaphth-2-yl)propionyloxy]-2-methyl-N-(2-pyridinyl)-2H-1,2-b enzothiazine-3-carboxamide 1,1-dioxide. |