| 摘要 |
PURPOSE:To industrially and sdvantageously obtain the titled compound useful as an edulcorant, by esterifying alpha-L-aspartyl-L-phenylalanine in a medium compound of sulfuric acid, water and methanol in the coexistence of an alkali (or alkaline earth) metal halide. CONSTITUTION:alpha-L-Aspartyl-L-phenylalanine is esterified in a medium compound of sulfuric acid, water and methanol in the coexistence of an alkali (or alkaline earth) metal halide (preferably magnesium chloride). Then the produced alpha-L- aspartyl-L-phenylalanine methyl eater is precipitated as a hydrohalide from the reaction system and the salt is isolated therefrom and, if necessary, neutralized to afford the aimed compound. The above-mentioned medium has 5-30wt% sulfuric acid concentration defined by sulfuric acid/(sulfuric acid+waterX100 and 3-35% methanol concentration defined by methanol/(methanol+water)X100.
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