| 摘要 |
PURPOSE:To obtain a 3'-deoxy-2'-ketoadenosine derivative useful as various intermediates in an extremely high yield, by treating a specific adenosine derivative with a metal alkoxide. CONSTITUTION:A compound expressed by formula I (R<1> and R<2> are trityl or dimethoxytrityl; R<3> is methanesulfonyl or toluenesulfonyl) is reacted with a metal alkoxide, e.g. magnesium methoxide, sodium lower alkoxide, in an amount of preferably 1-20mol equivalents, preferably at -70-+100 deg.C for 5min-12hr to afford the aimed compound expressed by formula II.
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