| 摘要 |
1295596 2 - Amino - imidazol - 2 - ine derivatives SYNTHELABO SA 19 April 1971 [12 March.1970] 23996/71 Heading C2C Novel 2 - amino - imidazoline - 2 - ine derivatives of the Formula I wherein n is 1 to 5 and acid addition salts thereof with pharmaceutical acceptable organic or mineral acids may be prepared by reacting an # - (diphenylamino - alkylamine with the hydrohalide of 2-methylthio-imidazol-2-ine in a refluxing hydroxyl containing polar solvent. The intermediate # - (diphenylamino)- alkylamine may be prepared by reduction of the corresponding nitrile. Pharmaceutical compositions of the compounds I show broncho-dilatatric and spasmolytic activity when administered orally, rectally, parenterally or by inhalation with a carrier or diluent.
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