摘要 |
PURPOSE:To obtain the titled compound, by subjecting p-phenylphenol to carbamating treatment with N-substituted carbamic acid chloride in an aromatic halogenated hydrocarbon, successively amidating the carbamate in the presence of Friedel-Crafts catalyst and further hydrolyzing the resultant amide. CONSTITUTION:p-Phenylphenol is subjected to carbamating treatment with N-substituted carbamic chloride (e.g. N,N-dimethylcarbamic acid chloride, etc.) expressed by formula I (R is alkyl or aryl) in an aromatic halogenated hydrocarbon (e.g. orthochlorobenzene, monochlorobenzene, etc.) to provide a compound expressed by formula II, which is successively amidated using the same carbamic acid chloride in the presence of Friedel-Crafts type catalyst [e.g. anhydrous aluminum chloride, anhydrous iron (III) chloride, etc.] added to afford a compound expressed by formula III, which is further hydrolyzed to give 4'- hydroxybiphenyl-4-carboxylic acid, useful as an intermediate of liquid crystal compound and polymer raw material. |