摘要 |
NEW MATERIAL:2-(1-Hydroxy-4-methyl-4-pentenyl)-1,4,5,8-tetramethoxyna- phthalene expressed by formula I. USE:A synthetic intermediate for shikonin, which is a herb medicine having excellent effects as a skin anti-inflammatory agent, antitumor agent and antimicrobial agent and has been regarded as a valuable also as purple of the ancients. PREPARATION:2-Formyl-1,4,5,8-tetramethylnaphthalene is reacted with a Grignard compound of 4-chloro-2-methyl-1-butene prepared by reacting the 4- chloro-2-methyl-1-butene with Mg in a solvent, e.g. tetrahydrofuran, etc., by a conventional method and the resultant product is then salted out, extracted with chloroform, etc., and purified by a conventional method to afford the aimed compound expressed by formula I.
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