| 发明名称 |
MODIFIED STRAINS OF BOVINE VIRAL DIARROHEA VIRUS |
| 摘要 |
<p>A live bovine viral diarrhoea (BVD) virus vaccine capable of producing immunity in bovines without causing significant side effects comprising a temperature sensitive (ts) mutant of BVD virus which is obtained by mutating a strain of BVD virus with nitrous acid. The temperature sensitive mutants show a replication ability considerably limited at the animal body temperature of 39.5 DEG C. The vaccine may be combined with other live bovine vaccines such as respiratory virus vaccines and then administered to bovines.</p> |
| 申请公布号 |
AU572050(B2) |
申请公布日期 |
1988.04.28 |
| 申请号 |
AU19830018529 |
申请日期 |
1983.08.30 |
| 申请人 |
SMITH KLINE- RIT, |
发明人 |
JEAN-CLAUDE DELGOFFE;MICHELE LOBMANN;NATHAN ZYGRAICH |
| 分类号 |
C12N7/00;A61K39/12;A61K39/15;A61K39/215;A61P31/12;C12N5/00;C12N7/06;C12R1/91;C12R1/92;(IPC1-7):A61K39/12 |
主分类号 |
C12N7/00 |
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