摘要 |
<p>Certain 5-oxo-3-(unsubstituted-phenyl)- or 5-oxo-3- (substituted-phenyl)-2-pyrrolidinepropanoic acids and 5-oxo-.beta.- (unsubstituted-phenyl)- or 5-oxo-.beta.-(substituted-phenyl)-2-pyrrolidinepropanoic acids, their pharmaceutically acceptable esters and metal and amine cation salts, pharmaceutical compositions employing these compounds, and a method of treating senility or of reversing amnesia are disclosed. The compounds have the general formula: (I) or (II) wherein * represents an asymmetrical carbon center, R represents H, phenyl, phenylmethyl or C1-6alkyl, and X and Y, independently, represent H, Cl, -CF3, C1-6alkyl or C1-6alkoxy.</p> |