| 摘要 |
PURPOSE:To obtain an antitumor agent showing strong antitumor action with a small amount of combined drugs, having low side effects, by combining leuckocytosis promoting factor (LPF) with a filamentous haemagglutinin (FHA) and interferon-alpha (IFN-alpha) active substance. CONSTITUTION:LPF having biological activities such as leukocytosis promoting action, histamine sensitizing action, insulin secretion enhancing activity, hemagglutination ability, etc., and/or FHA having biological activities such as hemagglutination ability, cell adsorption ability, etc., is combined with IFN-alpha active substance having antiviral action and antitumor action. IFN-alpha active substance having 1.5X10<8>-3.0X10<8> unit/mg specific activity, LPF having 40,000-50,000 ELISA unit/mg protein specific activity and FHA having 8,000-15,000 HA unit/mg protein specific activity are used in a blending ratio of LPF (FHA) and LFN-alpha active substance of 10-80mug protein: 1X10<5>-80X10<8> unit, preferably 10-15mug protein: 1X10<5>-10X10<8> unit. |
