SHORT CHAIN OLIGOSACCHARIDES HAVING BIOLOGICAL PROPERTIES, A PROCESS FOR MAKING THE SAME AND THE USE THEREOF AS DRUGS

摘要

1. Claims for the Contracting States : BE, CH, DE, GB, IT, LI, LU, NL, SE Short chained oligosaccharide compositions, characterized in that they are formed essentially of hexasaccharides having the sequence denoted below by the abreviation C'-H : see diagramm : EP0064452,P18,F1 in which R represents a hydrogen atom or the -SO3 - group and their physiologically acceptable salts. 1. Claims for the Contracting State : AT A process for the preparation of short chained oligosaccharide compositions, having the sequence denoted below by the abreviation C'-H : see diagramm : EP0064452,P19,F1 in which R represents a hydrogen atom or the -SO3 - group and their physiologically acceptable salts, characterized in that octasaccharides corresponding to the sequence ABCDEFGH (denoted below by the abreviation A-H), of the formula see diagramm : EP0064452,P20,F1 or octasaccharide compositions formed to a large extent of these octasaccharides, having a high ratio of their Yin-Wessler titer to their APTT or USP titer, are contacted, in a calcium containing buffer medium, with an enzymatic agent, said enzymatic agent having an enzymatic activity of at least 90 000 units and being applied at 0,25 to 1 mg per mg of octasaccharides treated, preferably of the order of 0.5 mg of enzymes per mg of octasaccharides, which enables to specifically fragment these octasaccharides in order to eliminate A-B units, and the major part of the active hexasaccharides C'-H are separated from the degradation mixture.