发明名称 |
Process and intermediates for the synthesis of the enantiomers of bicyclo(4.2.0)oct-2-en-7-one and derivatives and for the synthesis of bicyclo(4.2.0)octane derivatives. |
摘要 |
<p>The enantiomers of formulas <CHEM> are prepared in a sequence starting from the racemic compound of formula <CHEM> wherein X is hydrogen or bromo when Y is bromo, or X is chloro when Y is chloro. The key step of this process involves a microbial reduction of the compound of formula (3) to give a ketone and an alcohol of high enantiomeric purity. The compounds of formulas (1) and (2) are intermediates for the preparation of certain bicyclo[4.2.0]octane derivatives.</p> |
申请公布号 |
EP0257610(A2) |
申请公布日期 |
1988.03.02 |
申请号 |
EP19870112251 |
申请日期 |
1987.08.24 |
申请人 |
SYNTEX (U.S.A.) INC. |
发明人 |
KLUGE, ARTHUR F.;KERTESZ, DENIS J. |
分类号 |
C07C27/00;C12P41/00;A61K31/12;A61P9/00;C07C29/143;C07C29/58;C07C35/31;C07C35/52;C07C45/00;C07C45/29;C07C45/30;C07C45/60;C07C45/65;C07C47/267;C07C47/27;C07C47/273;C07C47/277;C07C49/553;C07C49/557;C07C49/687;C07C49/693;C07C49/743;C07C51/353;C07C59/46;C07C231/12;C07C67/00;C07C69/732;C07C231/00;C07C233/25;C07C239/00;C07C275/04;C07F7/18;C12P7/02;C12R1/865 |
主分类号 |
C07C27/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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