发明名称 TETRAHYDRO-1,3-THIAZINE-2,4-DIONES, THEIR USE AND AGENTS CONTAINING THESE COMPOUNDS FOR THE TREATMENT OF THE SKIN
摘要 <p>Skin treating composition on the basis of compatible carrier and additional compositions with a content of a defined tetrahydro-1,3-thiazine-2,4-dion derivatives as active ingredients for thickening the epidermis. The skin treating compositions are applied 1-2 times daily onto the skin for about 3 to 4 weeks. Due to the thickening of the epidermis they cause a reinforcmenet of the skin, in particular against sun rays, cold and the contact with noxious environmental substances of all kinds. Moreover, the skin treating compositions are suitable for a proplylactic fighting of the so-called old age skin. An object of the invention are novel tetrahydro-1,3-thiazine-2,4-dion derivative which are active in the aforementioned manner having the formula <IMAGE> wherein R denotes H, alkyl, aryl, arylalkyl has substituted arylalkyl or substituted aryl in the aryl portion, Ra=H is aryl or substituted aryl, Rb=H, denotes aryl or substituted aryl and Rc-H, represents alkyl or aryl, provided that Ra, Rb and Rconly simultaneously denote H when R denotes a substituted arylalkyl in the aryl portion and R denotes H, but only if Ra=HRb=aryl and Rc constitute=H.</p>
申请公布号 EP0116318(B1) 申请公布日期 1988.03.02
申请号 EP19840100530 申请日期 1984.01.19
申请人 WELLA AKTIENGESELLSCHAFT 发明人 HANEFELD, WOLFGANG, PROF.DR.;ROTHLISBERGER, RUDI, DR.;NOSER, FRIEDRICH, DR.
分类号 A61K8/00;A61K8/49;A61K31/54;A61Q17/04;A61Q19/00;A61Q19/08;C07D279/04;C07D279/06;C07D417/04;(IPC1-7):A61K7/48 主分类号 A61K8/00
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