| 摘要 |
<p>There are described novel quinazolinone compounds of the formula: …<CHEM>… wherein R is hydrogen atom or a lower alkyl, R<1> is a lower alkyl, a substituted or unsubstituted phenyl or an aralkyl, and R<2>, R<3>, R<4> and R<5> are the same or different and are each hydrogen atom, a halogen atom, a lower alkyl, a lower alkoxy, a lower alkoxycarbonyl or a lower alkoxycarbonyl-lower alkenyl, or two adjacent groups of R<2>, R<3>, R<4> and R<5> when taken together form methylenedioxy and the other two are hydrogen atom, and salts thereof. The compounds are useful for the prophylaxis and treatment of various diabetic complications. There are also disclosed processes for the preparation of compound of formula I, and pharmaceutical compositions containing such compound as an active ingredient.</p> |
