| 发明名称 | Degradable polyacrylamide gel | ||
| 摘要 | A degradable polyacrylamide gel for analyzing or separating at least one macromolecule in a sample using electrophoresis includes a polyacrylamide cross-linked with at least one degradable cross-linker having a ketal or acetal group with the formula (I), wherein R1 and R2 are the same or different and are hydrogen, an alkyl, or a substituted alkyl. | ||
| 申请公布号 | US9395330(B2) | 申请公布日期 | 2016.07.19 |
| 申请号 | US200812051680 | 申请日期 | 2008.03.19 |
| 申请人 | Case Western Reserve University | 发明人 | Kwon Young Jik |
| 分类号 | G01N27/447 | 主分类号 | G01N27/447 |
| 代理机构 | Tarolli, Sundheim, Covell & Tummino LLP | 代理人 | Tarolli, Sundheim, Covell & Tummino LLP |
| 主权项 | 1. A degradable polyacrylamide gel for analyzing or separating at least one macromolecule in a sample using electrophoresis, the degradable polyacrylamide gel comprising: at least one degradable cross-linker including a ketal or acetal group having the formula (I): wherein R1 and R2 are the same or different and are hydrogen, an alkyl, or a substituted alkyl; and an acrylamide polymer cross-linked with the at least one degradable cross-linker, the cross-linker being hydrolysable with an acid haying a pH of 3 to 5 after electrophoresis of the sample to release the macromolecule structurally intact. | ||
| 地址 | Cleveland OH US | ||