BONDED CHROMATOGRAPHIC STATIONARY PHASE

摘要

An organic compound is bonded to a powdered solid support to produce, for example, a chromatographic stationary phase, by introducing to a bed of the powdered material the vapour of a precursor of the compound to be bonded which precursor is selected from those which produce a gas phase by-product of the bonding reaction. The gas generated by the reaction is utilised as the fluidising gas. This permits the use of fluidised bed techniques on extremely low particle size powders. One example is the reaction of alkylchlorosilanes with silica gel to produce stationary phases with bonded carbon chains, derived from the alkyl groups, of up to 24 carbon atoms. A second feature of the method is the hydrothermal pretreatment of the bed of powder with steam to precondition the support.