| 摘要 |
NEW MATERIAL:A compound shown by formula I [R<1> is pyridyloxy (which may contain substituent group such as halogen, cyano, nitro, lower alkyl, carboxyl, lower alkoxycarbonyl, OH, etc.); R<2> is (phenyl)lower alkoxy lower alkyl, group shown by formula II or formula III (R<3> is H, lower alkanoyloxy; R<4> is H, lower alkanoyloxy, phenyl lower alkoxy, etc; R<5> is H, methyl, tec.)]. EXAMPLE:3-{[ 3-Cyano-6-(2,4-dichlorobenzoyloxy)-2-pyridyloxy ]carbonyl}-5-fluoro-1-( 2-tetrahydrofuranyl )uracil. USE:A carcinostatic agent having improved absorption, improved stability and low side effects such as reduction in weight, etc. PREPARATION:For example, first a compound shown by formula R<1>H is reacted with a compound shown by formula IV (X is halogen) and then the prepared compound shown by formula V is reacted with a compound shown by formula VI (R<2a> is R<2> except group shown by formula III). |
