INTERLEUKIN-2 INDUCED ANTI-TUMOR PEPTIDE

摘要

Methods and compositions are provided for production of novel polypeptides having antineoplastic activity. Polypeptides are obtained by lymphokine activation of killer lymphocytes, solubilizing peptides from the cells with acidic ethanolic extraction and purification using chromatography. The resulting peptides may be prepared by other techniques, such as synthesis or expression in nonmammalian or mammalian host cells. The peptides find use in inhibition of neoplastic cell proliferation.