| 摘要 |
Triazole derivs. of formulae (I) and (II) are new: (R1=CONH2, CSNH2 or C(NH)NH2 (and the physiologically acceptable acid addn. salts thereof); X=Hor 1-18C acyl at least one X is H and at least one is acyl; R = H or 1-18C acyl). Also claimed are teh hydrolysis prods. of (II). i.e. a mixt. of corresp. 2'-and 3'-monophosphates. Cpds. are antivirals. In a trial swiss mice were infected with 3.2 LD50 doses of influenza A2 virus (Japan 305). Only 1 untreated mouse of 20 survived (survival time 7.1 days) while mice give 300 mg/kg/day of 1-(5-butyryl-beta-D-ribofuranosyl)-1,2,4-triazole-3-carboxamide survived 9.6 days (5 out of 10 survivors.
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