发明名称 |
TERMENTATION PROCESS FOR OBTAINING AN ANTITUMORAL COMPLEX |
摘要 |
<p>An antitumor antibacterial complex having a quinoline nucleas referred to as BBM-928 is described which is produced by microbiological fermentation under controlled conditions using a species of actinomycetes. The bioactive components of the complex have pronounced antitumor activity and are moderately to weakly active against gram-positive and acid fast bacteria but practically inactive against gram- negative bacteria and fungi. Based on median survival time, the component designated BBM-928A is substantially more active than mitomycin C by a factor of 10 to 300 fold against intraperitoneally implanted mouse tumors.</p> |
申请公布号 |
YU41700(B) |
申请公布日期 |
1987.12.31 |
申请号 |
YU19800000812 |
申请日期 |
1980.03.24 |
申请人 |
BRISTOL-MYERS COMPANY |
发明人 |
KOSHIYAMA H.;SAKAI F. |
分类号 |
C07G99/00;A61K35/74;A61K38/00;A61P31/04;A61P35/00;C07G11/00;C07K7/06;C07K11/00;C07K14/195;C07K14/41;C12P1/06;C12P21/02;C12P21/04;C12R1/01;C12R1/03;C12R1/465;(IPC1-7):C07C103/52;A61K37/02 |
主分类号 |
C07G99/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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