发明名称 |
PREPARATION OF 1-ETHOXY-CARBONYLOXYETHYL ESTER OF 6-(-)- ALPHA-AMINO-ALPHA PHENYLACETAMIDO)PENICILLANIC ACID |
摘要 |
<p>alpha -Bromo diethylcarbonate is used to prepare ethylcarbonyloxyethyl esters of penicillins and caphalosporins. The amino group in ampicillin can first be protected by reaction with an acetoacetate derivative and the protecting group removed after the esterification step. alpha -Bromo diethylcarbonate can be used without an esterification catalyst and is obtained by reacting acetaldehyde with carbonyl bromide followed by reaction with ethanol or by a halogen exchange reaction with the corresponding alpha -chloro compound.</p> |
申请公布号 |
AU566803(B2) |
申请公布日期 |
1987.10.29 |
申请号 |
AU19830016328 |
申请日期 |
1983.06.28 |
申请人 |
ASTRA LAKEMEDEL AKTIEBOLAG |
发明人 |
LUIGI RATTI;DEREK REGINALD PALMER;ROBERT GRAHAM TYSON |
分类号 |
A61K31/43;A61P31/04;B01J31/02;C07B61/00;C07C68/02;C07C69/96;C07D499/00;C07D499/04;C07D499/08;C07D499/32;C07D499/44;C07D499/64;C07D499/68;C07D501/04;(IPC1-7):C07C69/96;C07C71/00 |
主分类号 |
A61K31/43 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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