NOVEL GLUCOSE DERIVATIVE

摘要

There are described 1,6-anhydro- beta -D-glucopyranose derivatives of the formula I in which R<1> is azido or amino, R<2> is hydrogen or a hydroxyl protective group, R<3> is hydrogen or lower alkyl and R<4> is hydroxyl, lower alkoxy or a radical of the formula II, in which n is 0 or 1, R<5> is hydrogen or lower alkyl, R<6> is hydrogen or lower alkyl which is unsubstituted or substituted by hydroxyl, lower alkanoyloxy or phenyl, R<7> and R<9> independently of one another are hydroxyl, amino, lower alkoxy, aryl-lower alkoxy or lower alkanoyloxy- lower alkoxy, and R<8> is hydrogen or lower alkyl which is unsubstituted or substituted by amino, hydroxyl, lower alkanoylamino, lower alkanoyloxy or guanidino, and positional isomers in which the position of the R<2> radical is interchanged with that of the group -CH(R<3>)-CO-R<4>, and salts of such compounds with at least one salt-forming group. These compounds are intermediates for a plurality of purposes, for example for the preparation of known or novel muramyl peptides. They allow a multitude of substituents to be introduced into the 1- and 2-position of the sugar moiety. Moreover, those compounds of the formula I in which R<1> is amino and R<4> is a radical of the formula II, are immunostimulants.