Treatment of memory impairment using (R)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide

摘要

(R)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide, its preparation and pharmaceutical compositions containing the same. It can be prepared either by reacting (R)-alpha-ethyl-2-oxo-1-pyrrolidineacetic acid successively with an alkyl haloformate and with ammonia, or, by cyclizing an (R)-2-amino-butanamide of the formula X-CH2CH2-Y-NHCH(C2H5)CONH2 wherein Y is a -CH2- radical when X represents a ZOOC- radical and Y is a -CO- radical when X represents a HalCH2- radical, Z being a C1-C4 alkyl radical and Hal a halogen atom. This dextrorotatory enantiomer has been found to have significantly higher mnemic activity and lower toxicity than the corresponding racemate.