| 摘要 |
NEW MATERIAL:A compound of formula I [2-4 of E and X-Z are C and the other 0-2 are H; 1-3 of A, B and D are C and the other 0-2 are N or S (provided that when A=D=N, then E and X-Z are not C at the same time); R<1> and R<2> are H, OH, halogen, lower alkyl, lower alkoxy, NH2, etc.; R<3>-R<5> are H, lower alkoxy, lower alkyl or adjacent two groups together form group of formula IV (R<6> is H or lower alkyl)] or its pharmacologically permissible salt. EXAMPLE:2-[[( 3,5-Dimethyl-4-methoxy-2-pyridyl )methyl-thio-1H-imidazo[4,5-b] pyridine. USE:An gastric acid secretion suppressing agent and antiulcer agent useful as a preventive and remedy for gastric diseases. PREPARATION:Reaction of the compound of formula II with the compound of formula III (X is halogen) gives the compound of formula Ia, which is treated with an oxidizing agent to obtain the compound of formula Ib. |
