| 摘要 |
PURPOSE:To obtain a novel antitumor agent, by fermenting grain by Rhizopus oryzae M-24 strain, collecting a water-soluble component in the fermented solution. CONSTITUTION:Grain such as polished rice, waste rice, etc. is fermented by Rhizopus oryzae M-24 strain (FERM-P 7195) by koji process. The koji is extracted with water to give a water-soluble substance, which is subjected to spray drying, to give an antitumor agent. This antitumor agent has the following physical properties. Elemental analysis value (about): C 40%, H 7%, and N 1%. Molecular weight: 5,000-100,000. Melting point: decomposing at >=220 deg.C. Solubility in solvent: easily soluble in water, insoluble in methnol, ethanol, chloroform, ether, acetone, ethyl acetate, and n-hexane. Color of substance: white. Saccharide content: 85-90wt% calculated as glucose measured by phenol-sulfuric acid method. |
