ANTIBIOTIC SUBSTANCE, PRODUCTION AND USE THEREOF

摘要

NEW MATERIAL:A 2-(4-substituted amino-3-oxo-2-isoxazolidinyl)-5-oxo-2- tetrahydrofurancarbox-ylic acid derivative expressed by formula I (R<1> is amino or organic residue through N; R<2> is COOH or a group derived therefrom; X is H, methoxy or formylamino, provided that R<2> is not p-nitrobenzyloxycarbonyl or benzhydryloxycarbonyl when R<1> is acetylamino or amino and X is H). EXAMPLE:Sodium 2-{(4S)-4-[2-(2-amino-4-thiazolyl)-(Z)-2-(methoxyimino)acet- amido]-3-oxo-2-isoxazolidinyl}-5-oxo-2-tetrahydrofurancarbo-xylate. USE:A low toxic antimicrobial agent against Gram-positive and Gram-negative bacteria. PREPARATION:A compound expressed by formula II is reacted with a compound capable of introducing a group forming an organic residue through N.