| 摘要 |
<p>Peptides of formula (I), wherein NH is the α amino group of amino acid AA1; (II) is the carbonyl group of amino acid AA7; X is H-, (III), GLU-VAL-, or VAL-TYR-HIS-GLU-VAL; Y is -OH, -NH¿2?, or -PRO; AA?1¿ is LYS, GLU, GLN, pGLU, βALA, PRO, PRO-OH, PIC, or AIB; AA2 is VAL, LEU, ILE, MET, or AIB; AA3 is ASP, TYR, GLU, HIS, or PHE; AA4 is VAL, MET, ILE, LEU, or AIB; AA5 is TYR, HIS, or GLU; AA6 is ALA, PRO, SER, βALA, PRO-OH, or AIB; and AA7 is VAL, LEU, ILE, or AIB; and salts thereof are claimed as effective blood pressure regulators. Further provided, are antibodies to these peptides, as well as diagnostic and therapeutic methods for blood pressure regulation.</p> |
