| 摘要 |
The use is claimed of N-phenyl-N'-phenalkyl- (2-5C) alkylenediamines of formula R1-NR2-A-NR3-B-R4 (I, certain of which are new, or their pharmaceutically acceptable salts or solvates, for the prepn. of a medicament for the treatment or prophylaxis of angina where R1, R4 = phenyl opt. substd. by 1-3 of halogen, CF3, 1-4C alkyl, 1-4C alkoxy, CN, OH, NO2, NR5R6 or SO2NR5R6, or disubstd. on adjacent C atoms by 1-2C alkylenedioxy and opt. further substd. by one of the above gps. R5,R6 = H or 1-6C alkyl or together are 3-6C polymethylene, R2 = (CH2)zCN, 1-12C alkyl, 3-7C cycloalkyl, 3-7C cycloalkyl- (1-4C)alkyl, phenyl-(1-4C)alkyl, pyridyl, pyridyl-(1-4C)alkyl, COR7, COCH2COR7, SO2R7, CO2R7, CONHR7 or CSNHR7, any pyridyl or phenyl gp. in R2 opt. being substd. as for R1 and R4 and any cycloaklyl gp. in R2 opt. being substd. by 1 or 2 (1-4C)alkyl gps. R7 = 3-12C alkyl, 3-7C cycloalkyl, 3-7C cycloalkyl-(1-4C)alkyl, phenyl or phenyl-(1-4C) alkyl, any alkyl gp. being opt. substd. by OH or 1-4C alkanoyloxy; R3 = H or 1-4C alkyl; A = 2-5C alkylene; and B = 1-4C alkylene. (I) are new provided that (R1,R2,A,R3,B,R4) are not the following combinations: (3,4-dimethoxyphenyl, Et, (CH2)2, H, (CH2)2, phenyl), (3,4-dimethoxyphenyl, Et, (CH2)2, H, CH2, phenyl), (Ph, COnPr, (CH2)2, Me, CH2,Ph), (Ph,COiPr, (CH2)2, Me, CH2, Ph), (Ph, COnPr, CH(Me)CH2, Me,(CH2)2,Ph) (PH,ConPr (Ph,COnBu,CH2CHMe,Me,(CH2)2,Ph), (Ph,PhCH2,(CH2)2, H,(CH2)2,Ph), (Ph,PhCH2,(CH2)2,Me,CH2,Ph), (Ph,PhCH2.(CH2)2,Me,(CH2)2,Ph), (Ph,PhCH2,(CH2)2,Me,(CH2)3,Ph), (4-Cl-Ph, PhCH2,(CH2)2, H,(CH2)2,Ph), (4-Cl-Ph,PhCH2,(CH2)2, Me,(CH2)2,Ph), (Ph,4-Cl-PhCH2-, (CH2)2,Me,(CH2)2,Ph), (Ph,PhCH2,(CH2)2,4-Cl-Ph). |
