| 摘要 |
<p>2-(N-substd. aminoalkanoylamino)-1- (N-heterocyclyl)-alkanols of formula X-(NH-CHR5-CO)p-NH-CHR4- CO-NH-CHR3-CHOH-R1 (I) and their salts are new, where X=R6-(CH2)m-, R6-(CH2)m-C-(-NH-CHR10-CO=-q, R6-(CH2)m-O-CO-, R6-O-(CH2)n-CO-, R6-(CH2)m-NH-CO-, R6-(CH2)m-SO2-, R6-(CH2)m-CH((CH2)m'-R6')-CO- or gp (a) or (b) R3-R5,R10=H, lower alkyl, halo substd. lower alkyl, -(CH2)n-aryl, -(CH2)n-heterocyclo, -(CH2)n-OH, -(CH2)n-O-lower alkyl, -(CH2)n-NH2, -(CH2)n-SH, -(CH2)n-S-lower alkyl, -(CH2)n-O-(CH2)g-OH, -(CH2)n-O-(CH2)g-NH2, -(CH2)n-S-(CH2)g-OH, -(CH2)n-COOH, -(CH2)n-S-(CH2)g-NH2, -(CH2)n-cycloalkyl, -(CH2)n-NH-Cl=NH)-NH2, -(CH2)nCONH2 or gp or (c) or (d) R6 and R'6 =lower alkyl, cycloalkyl, aryl or heterocyclo; p and q=0 or 1; m and m'=0-5; n=1-5; g=2-5; R7=-CH2OCH2Ph or -CH2Ph; R8=2,4-dinitrophenyl, -COOCH2Ph, p-toluenesulphonyl or -CH2OCH2Ph; R1=(i) fully or partially satd or unsatd monocyclic N-hetero-cyclic ring of 5 or 6 atoms contg at least one N atom or (ii) a biscyclic ring in which ring (i) is fused to a benzene ring; ring (i) can also include and O or S atom or up to three additional N-atoms.</p> |
