| 摘要 |
NEW MATERIAL:An acylamino acid derivative of formula I (n is integer of 0-6; R<1> is 5-25C saturated or unsaturated fatty acid residue; R<2> is H; R<3> is H, 3-5C branched alkyl, phenyl, hydroxyphenyl, aralkyloxyphenyl, indolyl, imidazolyl, methylthio or R<2> and R<3> together form a bond between C and N). EXAMPLE:N-Oleoyl-L-phenylalanylpyrrolidine. USE:A prolylendopeptitase-activity inhibitor effective in improving and curing symptoms of psychic function caused by cerebral organic disorder, especially amnesia. PREPARATION:The compound of formula I can be produced by reacting a compound of formula R<1>-A or R<1>-O-R<1> (A is OH or halogen) with a compound of formula II in the presence of a base preferably trialkylamine or pyridine base. |
