发明名称 |
Metal complexes of bis-indole compounds and aqueous pharmaceutical compositions containing them |
摘要 |
The invention relates to new aqueous pharmaceutical compositions containing as active ingredient a pharmaceutically acceptable complex of a bis-indole compound with a bi- or multivalent metal ion in a therapeutically effective amount. The invention further relates to complexes formed between a bis-indole compound and a bi- or multivalent metal ion. According to another aspect of the invention there is provided a process for the preparation of a pharmaceutically acceptable metal complex of a bis-indole compound and optionally stable aqueous pharmaceutical compositions containing said metal complex, in which a solution of a bis-indole compound or a pharmaceutically acceptable salt thereof in an aqueous medium is reacted with a non-toxic water soluble salt of a bi- or multivalent metal capable of complexation, at a pH of 3.0 to 6.0, optionally in the presence of or followed by the addition of a conventional pharmaceutical carrier and/or further additive, or, if desired, the obtained complex is isolated. The aqueous pharmaceutical compositions according to the invention have substantially increased stability.
|
申请公布号 |
US4684638(A) |
申请公布日期 |
1987.08.04 |
申请号 |
US19850782492 |
申请日期 |
1985.10.01 |
申请人 |
RICHTER GEDEON VEGYESZETI GYAR RT. |
发明人 |
NAGY, GEZA T.;SZEPESI, GABOR;GAZDAG, MARIA;PAPP NEE SZIKLAY, ZSOFIA;BURGER, KALMAN |
分类号 |
A61K9/00;A61K9/08;A61K31/475;A61K31/555;A61K47/26;A61P35/00;C07D519/04;C07F3/02;C07F3/04;C07F3/06;(IPC1-7):A61K31/475 |
主分类号 |
A61K9/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|