BETA-LACTAME DERIVATIVE

摘要

NEW MATERIAL:A compound of formula I (R is protecting group for hydroxyl). EXAMPLE:(1'R,3S,4R)-3-1'-(t-Butyldimethylsilyloxy)ethyl-4-1''-(tiazolid ine-2-thione- 3-carbonyl)ethyl-azetidine-2-one. USE:A synthetic intermediate of 1beta-methylcarbapenem which discloses excellent antibacterial action. PREPARATION:The reaction of 4-acetoxy-beta-lactame derivative of formula II with 3-propionylthiazolidine-2-thione tin(II) enolate stereospecifically gives the compound of formula I.