| 摘要 |
Compounds of formula (I), and pharmaceutically acceptable salts thereof: <CHEM> wherein L is NH or O; X and Y are independently selected from hydrogen or C1-4 alkyl, or together are a bond; R1 and R2 are independently selected from hydrogen, C1-6 alkyl, C2-6 alkenyl-C1-4 alkyl, or together are C2-4 polymethylene; R3 and R4 are independently selected from hydrogen, halogen, CF3, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, C1-7 acyl, C1-7 acylamino, C1-6 alkylsulphonylamino, N-(C1-6 alkylsulphonyl)-N-C1-4 alkylamino, C1-6 alkylsulphinyl, hydroxy, nitro or amino, aminocarbonyl, aminosulphonyl, aminosulphonylamino or N-(aminosulphonyl)-C1-4 alkylamino optionally N-substituted by one or two groups selected from C1-6 alkyl, C3-8 cycloalkyl, C3-8 cycloalkyl C1-4 alkyl, phenyl or phenyl C1-4 alkyl groups or optionally N-disubstituted by C4-5 polymethylene; Z is a group of formula (a), (b) or (c) <CHEM> wherein n is 2 or 3; p is 1 or 2; q is 1 to 3; r is 1 to 3; and R5 or R6 is C1-7 alkyl, C3-8cycloalkyl, C3-8 cycloalkyl-C1-2 alkyl or C2-7 alkenyl-C1-4 alkyl; having 5-HT M-receptor antagonist activity, a process for their preparation and their use as pharmaceuticals. |
