发明名称 |
2-THIACEPHEMS AND 5R PENEMS DERIVATIVES |
摘要 |
<p>A new process is described for the preparation of (5R)-penem derivatives of the general formula I: <IMAGE> I wherein R1 represents a hydrogen atom or an organic group; R2 represents a hydrogen atom or a carboxy protecting group and Y represents a hydrogen or halogen atom or an organic group. A 2-thiacephem derivative of the general formula II: <IMAGE> II wherein R1, R2 and Y have the meanings/given above is oxidized by means of organic peracids to the corresponding sulphone of the general formula III: <IMAGE> III which is subsequently submitted to a desulphurative ring contraction by extrusion of SO2 to give exclusively the desired (5R)-penem derivatives of the general formula I.</p> |
申请公布号 |
AU563157(B2) |
申请公布日期 |
1987.07.02 |
申请号 |
AU19830021901 |
申请日期 |
1983.12.01 |
申请人 |
FARMITALIA CARLO ERBA S.P.A. |
发明人 |
MARCO ALPEGIANI;ANGELO BEDESCHI;MAURIZIO FOGLIO;GIOVANNI FRANCESCHI;ETTORE PERRONE |
分类号 |
C07D205/09;C07D417/12;C07D499/06;C07D499/86;C07D499/861;C07D499/87;C07D499/88;C07D499/897;C07D513/04;C07F7/18;(IPC1-7):C07D499/00;C07F7/10 |
主分类号 |
C07D205/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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