发明名称 |
Medical device for pulsatile transdermal delivery of biologically active agents. |
摘要 |
The present invention relates to A medical device for the pulsatile administration of a drug through intact skin at a first steady state flux during a first delivery period and a second steady state flux during a second delivery period, said first flux being substantially higher than said second flux; said first and second delivery periods comprising a substantial portion of a predetermined administration period, characterised in that said device comprises:
a) a reservoir of said drug containing an amount of drug sufficient to adminster drug at said first and second steady state fluxes throughout said administration period;
b) a reservoir of a skin permeation enhancer for said drug; said reservoir containing an amount of said permeation enhancer sufficient to permit administration of said drug at said first flux only through said first delivery period; and
c) means for maintaining said device on the skin in drug and permeation enhancer transferring relationship thereto.
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申请公布号 |
EP0227252(A2) |
申请公布日期 |
1987.07.01 |
申请号 |
EP19860308248 |
申请日期 |
1986.10.23 |
申请人 |
ALZA CORPORATION |
发明人 |
GALE, ROBERT M.;BERGGREN, RANDALL G. |
分类号 |
A61L15/64;A61K9/70;A61M35/00;A61M37/00 |
主分类号 |
A61L15/64 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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