发明名称 |
RIBOSOME INACTIVATED GLYCOPROTEINS |
摘要 |
Modified glycoproteins inhibiting ribosomes with a view to endowing them with a long period of activity in vivo, by oxidation of the oside units by reaction of periodate ions and simultaneous blocking of the oxidation product by forming a Schiff base with a suitable primary amine. These glycoproteins are suitable for obtaining immunotoxins with long in-vivo activity by coupling an antibody or an antibody fragment with such a glycoprotein. |
申请公布号 |
AU6663086(A) |
申请公布日期 |
1987.06.25 |
申请号 |
AU19860066630 |
申请日期 |
1986.12.17 |
申请人 |
SANOFI |
发明人 |
PIERRE CASELLAS;BERNARD BOURRIE;XAVIER CANAT |
分类号 |
C07K14/00;A61K36/00;A61K36/18;A61K36/42;A61K36/896;A61K38/00;A61K38/36;A61K39/395;A61K47/48;A61P35/00;C07K1/107;C07K1/113;C07K14/415;C07K14/42;C07K19/00 |
主分类号 |
C07K14/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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