发明名称 |
Thymidine kinase deletion mutants of bovine herpesvirus-1, vaccines against infectious bovine rhinotracheitis containing same and methods for the production and use of the same. |
摘要 |
<p>Bovine herpesvirus type 1 (infectious bovine rhinotracheitis virus) mutants which fail to produce any functional thymidine kinase as a result of a deletion in the thymidine kinase gene. The deletion in the thymidine kinase gene attenuates the viruses so that they can be used as an active agent in a modified live-virus vaccine against infectious bovine rhinotracheitis. This invention also relates to methods for the production and use of the same. </p> |
申请公布号 |
EP0226029(A1) |
申请公布日期 |
1987.06.24 |
申请号 |
EP19860115455 |
申请日期 |
1986.11.07 |
申请人 |
NOVAGENE LIMITED;BAYLOR COLLEGE OF MEDICINE |
发明人 |
KIT, MALON;KIT, SAUL |
分类号 |
C12N15/09;A61K39/245;A61K39/265;C12N7/00;C12N7/04;C12N15/00;C12Q1/70;C12R1/91 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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