PROCESS FOR THE PREPARATION OF AMINOGUANIDINE DERIVATIVES

摘要

1-Phenylaminoguanidine derivs, of formula(I)[R1R2, R3=H, halo, alkyl, NO2, CF3, alkoxy; R4,R5=alkyl or together 5-8 membered satd. hetenocycle contg. another N or O atom and (Un)substd. by 1 or 2 Me, CH2OH and/or HOCH2CH2; R6,R7=H, alkyl, alkenyl are prepd. Thus, a mixt. of 2-MeC6H4NHNH2,HCl, anhydn. PrOH, and N:CNMe2 is stirred at 130≦̸C and under N2 for 5hr to give 63.4% 1-(2-methylphenyl)-4, 4- dimethyl-aminoguanidine. HCl. (I) have antiarrhythmic and caridoprotectant activity and also are active against cardiac flicker.