| 摘要 |
NEW MATERIAL:The indeno[1,2-c]pyrazole derivative of formula [R is (branched) >=2C alkyl, epoxyalkyl, acyl or lower alkyl substituted with carboxyl, alkoxycarbonyl, carbamoyl, alkylcarbamoyl or dialkylcarbamoyl]. EXAMPLE:1-Methyl-3-(4-isobutoxyphenyl)indeno[1,2-c]pyrazol-4-(1H)-one. USE:Useful as a carcinostatic agent. It has tumor proliferation suppressing activity and is free from toxicity. PREPARATION:The compound of formula I can be produced by using 1- methyl-3-(4-hydroxyphenyl)indeno[1,2-c]pyrazol-4-(1H)-one as a raw material, converting the hydroxyl group to a metallic salt such as sodium salt and reacting with an acid anhydride, etc., in an inert solvent. |
